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Why wee is yellow?

Updated: 11/17/2022
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15y ago

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Some European alchemists in the middle ages apparently thought one possible reason was that there was gold in urine. This led to fruitless, and possibly quite disgusting, efforts to extract that gold.

The yellow color in urine is due to chemicals called urobilins. These are the breakdown products of the bile pigment bilirubin. Bilirubin is itself a breakdown product of the heme part of hemoglobin from worn-out red blood cells. Most bilirubin is partly broken down in the liver, stored in the gall bladder, broken down some more in the intestines, and excreted in the feces (its metabolites are what make feces brown), but some remains in the bloodstream to be extracted by the kidneys where, converted to urobilins, it gives urine that familiar yellow tint. (Here is a great diagram of some of these reactions, from the Boehringer Mannheim Biochemical Pathways at ExPASy.)

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