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When the father is Rh positive, it is possible that the child will also be Rh positive. Or, if the father is homozygous ++ or DD, then all of his children will be Rh positive.

When an Rh negative person is exposed to Rh positive blood, in this case during birth, they will develop antibodies against the Rh positive blood. This means that if they come in contact with Rh positive blood again, they have antibodies which will attack the Rh positive blood.

This is what happens when the mother is Rh negative and the foetus is Rh positive. There usually isn't a problem with the first pregnancy, because the mother might not have been exposed to Rh positive blood before. However, if the second foetus is also Rh positive, the antibodies in the mother's blood will attack the foetus. This ranges in severity, but can cause the death of the foetus.

In most cases this is preventable - the mother can receive an injection of anti-RhD immunoglobulin during pregnancy or soon after delivery.

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13y ago

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