Will a speeding ticket in CA affect driving record in MD?

Yes. Under the Interstate Driver's License Compact, California will notify Maryland of the conviction and Maryland will assess points on your license. If you fail to take care of the Cali ticket, MD will be notified and your driver's license will be suspended until the Cali matter is taken care of. Consult with an attorney because there may be other ramifications to your MD license based on the type of offense, etc.