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Will acetaminophen or phenacetin have a higher Rf if you carry out a TLC separation of on a silica gel using a non-polar developing solvent?
Wiki User
∙ 13y ago
Acetaminophen's solubility:
0.1-0.5 g/100 mL at 22 C (Very slightly soluble)
Phenacetin's solubility:
0.076 g/100 mL
Acetaminophen contains Amide & Alcohol groups, thus makes it really polar whereas Phenacetin contains Ether & Amine that are less polar.
Wiki User
∙ 13y ago
Wiki User
∙ 13y agophenacetin will have the higher Rf value because it is less polar. Nonpolar molecules travel more quickly through silica gel.
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