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No it will not. My husband had to take 1/2 the barium at night the night previous to CT scan, and then the rest the morning of the test. He also had blood work. We had appointments in 2 different clinics. We showed up to blood work and asked if it was possible to do tests, they said ok. After that we went for CT scan. When we got results, everything was OK, barium did not affect the blood work. This was on 4/25/2014.

Greetings from Sunny San Antonio, TX

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