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Ceruloplasmin is a copper-containing protein. This article discusses the test to measure the level of the protein in the clear liquid part of the blood (serum).
How the test is performedBlood is typically drawn from a vein, usually from the inside of the elbow or the back of the hand. The site is cleaned with germ-killing medicine (antiseptic). The health care provider wraps an elastic band around the upper arm to apply pressure to the area and make the vein swell with blood.
Next, the health care provider gently inserts a needle into the vein. The blood collects into an airtight vial or tube attached to the needle. The elastic band is removed from your arm.
Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.
In infants or young children, a sharp tool called a lancet may be used to puncture the skin and make it bleed. The blood collects into a small glass tube called a pipette, or onto a slide or test strip. A bandage may be placed over the area if there is any bleeding.
How to prepare for the testNo fasting or other preparation is usually needed.
How the test will feelWhen the needle is inserted to draw blood, you may feel moderate pain, or only a prick or stinging sensation. Afterward, there may be some throbbing.
Why the test is performedYour health care provider may order this test if you have signs or symptoms of a copper metabolism or copper storage disorder.
Normal ValuesNormal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.
What abnormal results meanLower-than-normal ceruloplasmin levels may indicate:
- Menkes' syndrome (Menkes' kinky hair syndrome) -- very rare
- Wilson's copper storage disease (rare)
Greater-than-normal ceruloplasmin levels may indicate:
- Pregnancy
- Lymphoma
- Acute and chronicinfections
- Rheumatoid arthritis
There is very little risk involved with having your blood taken. Veins and arteries vary in size from one patient to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.
Other risks associated with having blood drawn are slight but may include:
- Excessive bleeding
- Fainting or feeling light-headed
- Hematoma (blood accumulating under the skin)
- Infection (a slight risk any time the skin is broken)
Kowdley KV. Inherited and metabolic hepatic disorders. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 154.
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∙ 13y ago
Wiki User
∙ 12y agoCeruloplasmin is a copper-containing protein. This article discusses the test to measure the level of this protein in the clear liquid part of the blood (serum).
How the test is performedA blood sample is needed. For information on how this is done, see: Venipuncture.
How to prepare for the testNo fasting or other preparation is usually needed.
How the test will feelWhen the needle is inserted to draw blood, you may feel moderate pain, or only a prick or stinging sensation. Afterward, there may be some throbbing.
Why the test is performedYour health care provider may order this test if you have signs or symptoms of a copper metabolism or copper storage disorder.
Normal ValuesNormal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.
What abnormal results meanLower-than-normal ceruloplasmin levels:
- Chronic liver disease
- Intestinal malabsorption
- Malnutrition
- Menkes' syndrome (Menkes' kinky hair syndrome) -- very rare
- Nephrotic syndrome
- Wilson's copper storage disease (rare)
Higher-than-normal ceruloplasmin levels:
- Acute and chronicinfections
- Lymphoma
- Pregnancy
- Rheumatoid arthritis
Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.
Other risks associated with having blood drawn are slight but may include:
- Excessive bleeding
- Fainting or feeling light-headed
- Hematoma (blood accumulating under the skin)
- Infection (a slight risk any time the skin is broken)
Kowdley KV. Inherited and metabolic hepatic disorders. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 154.
Cox DW, Roberts EA. Wilson disease. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 9th ed. Philadelphia, Pa: Saunders Elsevier;2010:chap 75.
Reviewed ByReview Date: 02/21/2011
David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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Which carries copper in plasma proteins?
ceruloplasmin
What is Ceruloplasmin used for in the body?
Ceruloplasmin is an enzyme that is important in the human body. It is synthesized by the liver. It carries much copper and has a major role in iron metabolism.
What is an aceruloplasminemia?
An aceruloplasminemia is a lack of ceruloplasmin in the blood, or the disorder associated with it.
What is the ceruloplasmin?
A blood glycoprotein to which copper is bound during transport and storage.ceruloplasmin
Why do birth control hormones make plasma green in blood donors?
Birth control pills (BCPs) mimic pregnancy during which the lelvel of a copper containing protein ceruloplasmin is elevated. Just like oxidized copper turns green (verdigris= Copper ++) think statue of liberty!
What is Wilson's Disease?
it is a rare diorder of abnormal copper metabolism and is characterised by: hepatolenticular degeneration. copper get deposited in abnormal amounts in liver and lenticular nucleus of brain leading to necrosis of liver and brain. low level of copper and ceruloplasmin in plasma with increased excretion of copper in urine, copper deposition in kidneys causes renal damage. causes: failure in the synthesis of ceruloplasmin. excess copper in plasma. reduced intestinal excretion of copper. treatment: penicillamine.
Are there Genetic Diseases similar to Wilson disease?
I'm not a doctor. I don't know that the diagnoses of lyme and wilson's would normally overlap, but my husband is an atypical case. He has late stage neurological lyme disease and the doctors are testing him for Wilson's disease as a differential diagnosis. I think mostly to rule it out. HisLooking into Wilson's because:My husband is in his 20s,has dystonia and myoclonic jerks,as well as emotional and cognitive changes.Slightly elevated liver enzymeshis ceruloplasmin test came back in range, but on the very low end of normalHe doesn't recall a tickbite and never noticed a bullseye rash but has tested positive for lyme.
What has the author Mary Winchester Abbott written?
Mary Winchester Abbott has written books such as "Behind the Mask: The Life of Vita Sackville-West" and "A Russian Novel." She is known for her biographies of notable figures and her exploration of Russian art and culture.
What are the the properties of plasma?
(1) Plasma proteins are large molecules with molecular weights ranging mostly from 50,000 to 300,000 Daltons. (2) With the notable exception of albumin, nearly all plasma proteins are Glycoproteins, containing oligosaccharides. The oligosaccharide chains are responsible for certain properties of plasma proteins like solubility, viscosity, charge, denaturation etc. (3) like most other proteins, their charged residues tend to be located on the surface. (4) Many plasma proteins exhibit polymorphism. Polymorphism is a Mendelian trait that exists in the population in at least two phenotypes, neither of which is rare. Plasma proteins showing polymorphism are haptoglobin, transferring, ceruloplasmin, and immunoglobulin. Due to the large size of the protein molecules, (5) they can be separated from the plasma by ultracentrifugation (unlike electrolytes or other smaller molecules). (6) They are unable to pass across the capillary membrane and consequently exert an oncotic pressure of about 25 mm Hg. (7) Owing to their size and particularly their shape, they greatly contribute to blood viscosity. The plasma protein fibrinogen is a significant contributor to blood viscosity. Due to the presence of polar residues on their surfaces, (8) the protein molecules are soluble in water. (9) The molecules show electrophoretic mobility. (10) The molecules are amphoteric. This is because the polar residues comprise both NH2 and COOH groups.
What are (at least) 5 properties of water?
(1) Plasma proteins are large molecules with molecular weights ranging mostly from 50,000 to 300,000 Daltons. (2) With the notable exception of albumin, nearly all plasma proteins are Glycoproteins, containing oligosaccharides. The oligosaccharide chains are responsible for certain properties of plasma proteins like solubility, viscosity, charge, denaturation etc. (3) like most other proteins, their charged residues tend to be located on the surface. (4) Many plasma proteins exhibit polymorphism. Polymorphism is a Mendelian trait that exists in the population in at least two phenotypes, neither of which is rare. Plasma proteins showing polymorphism are haptoglobin, transferring, ceruloplasmin, and immunoglobulin. Due to the large size of the protein molecules, (5) they can be separated from the plasma by ultracentrifugation (unlike electrolytes or other smaller molecules). (6) They are unable to pass across the capillary membrane and consequently exert an oncotic pressure of about 25 mm Hg. (7) Owing to their size and particularly their shape, they greatly contribute to blood viscosity. The plasma protein fibrinogen is a significant contributor to blood viscosity. Due to the presence of polar residues on their surfaces, (8) the protein molecules are soluble in water. (9) The molecules show electrophoretic mobility. (10) The molecules are amphoteric. This is because the polar residues comprise both NH2 and COOH groups.
What does copper wire do?
Some things copper is used for are:Rooftops. It is best against erosion and is cheap, but over the years, it turns a light green due to a long-term chemical change.Copper is also used for copper wiring in houses because it is an amazing conductor of electricity.It is used for wiring alloys brass bronze and silverCopper tubing is used for some plumbing.Copper is used in jewelryIt is used in coinageCoffee pots and cooking pans are often made of copper.copper can be used for batteries, pots, pans, computers, pennies, phones, electricity, and transportation vehicles. It is also used for wiring. Hope that has helped (: xox
How is cirrhosis diagnosed?
The gold standard for diagnosis of cirrhosis is a liver biopsy, through a percutaneous, transjugular, laparoscopic, or fine-needle approach. Histologically cirrhosis can be classified as micronodular, macronodular, or mixed, but this classification has been abandoned since it is nonspecific to the etiology, it may change as the disease progresses, and serological markers are much more specific. However, a biopsy is not necessary if the clinical, laboratory, and radiologic data suggests cirrhosis. Furthermore, there is a small but significant risk to liver biopsy, and cirrhosis itself predisposes for complications due to liver biopsy.The following findings are typical in cirrhosis:Aminotransferases - AST and ALT are moderately elevated, with AST > ALT. However, normal aminotransferases do not preclude cirrhosis.Alkaline phosphatase - usually slightly elevated.GGT -- correlates with AP levels. Typically much higher in chronic liver disease from alcohol.Bilirubin - may elevate as cirrhosis progresses.Albumin - levels fall as the synthetic function of the liver declines with worsening cirrhosis since albumin is exclusively synthesized in the liverProthrombin time - increases since the liver synthesizes clotting factors.Globulins - increased due to shunting of bacterial antigens away from the liver to lymphoid tissue.Serum sodium - hyponatremia due to inability to excrete free water resulting from high levels of ADH and aldosterone.Thrombocytopenia - due to both congestive splenomegaly as well as decreased thrombopoietin from the liver. However this rarely results in platete count < 50,000/mL.Leukopenia and neutropenia - due to splenomegaly with splenic margination.Coagulation defects - the liver produces most of the coagulation factors and thus coagulopathy correlates with worsening liver disease.Other laboratory studies performed in newly diagnosed cirrhosis may include: Serology for hepatitis viruses, autoantibodies (ANA, anti-smooth muscle, anti-mitochondria, anti-LKM)Ferritin and transferrin saturation (markers of iron overload), copper and ceruloplasmin (markers of copper overload)Immunoglobulin levels (IgG, IgM, IgA) - these are non-specific but may assist in distinguishing various causesCholesterol and glucoseAlpha 1-antitrypsinUltrasound is routinely used in the evaluation of cirrhosis, where it may show a small and nodular liver in advanced cirrhosis along with increased echogenicity with irregular appearing areas. Ultrasound may also screen for hepatocellular carcinoma, portal hypertension and Budd-Chiari syndrome. Other tests performed in particular circumstances include abdominal CT and liver/bile duct MRI (MRCP). Gastroscopy (endoscopic examination of the esophagus, stomach and duodenum) is performed in patients with established cirrhosis to exclude the possibility of esophageal varices. If these are found, prophylactic local therapy may be applied (sclerotherapy or banding) and beta blocker treatment may be commenced. If biliary pathology is suspected, ERCP may be performed. Generally MRCP (MRI of biliary tract and pancreas) is sufficient for diagnosis, but ERCP allows for particular interventions, such as placement of a biliary stent or extraction of gallstones. Macroscopically, the liver may be initially enlarged, but with progression of the disease, it becomes smaller. Its surface is irregular, the consistency is firm and the color is often yellow (if associates steatosis). Depending on the size of the nodules there are three macroscopic types: micronodular, macronodular and mixed cirrhosis. In micronodular form (Laennec's cirrhosis or portal cirrhosis) regenerating nodules are under 3 mm. In macronodular cirrhosis (post-necrotic cirrhosis), the nodules are larger than 3 mm. The mixed cirrhosis consists in a variety of nodules with different sizes. Microscopically, cirrhosis is characterized by regeneration nodules, surrounded by fibrous septa. In these nodules, regenerating hepatocytes are disorderly disposed. Portal tracts, central veins and the radial pattern of hepatocytes are absent. Fibrous septa are important and may present inflammatory infiltrate (lymphocytes, macrophages) If it is a secondary biliary cirrhosis, biliary ducts are damaged, proliferated or distended - bile stasis. These dilated ducts contain inspissated bile which appear as bile casts or bile thrombi (brown-green, amorphous). Bile retention may be found also in the parenchyma, as the so called "bile lakes"1.1. http://en.wikipedia.org/wiki/Cirrhosis
