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CSF myelin basic protein is a test to measure the level of myelin basic protein (MBP) in the cerebrospinal fluid (CSF), the clear liquid that surrounds the brain and spinal cord.
MBP is found in the material that covers your nerves.
A sample of CSF is needed. The most common way to collect this sample is with a lumbar puncture, also called a spinal tap. See the article on lumbar puncture for details about this procedure.
Other methods of collecting CSF are rarely used, but may be recommended in some cases. They include:
- Cisternal puncture
- Ventricular puncture
- Removing CSF from a tube already in place in the CSF, such as a shunt or ventricular drain
After the sample is taken, it is sent to a laboratory for evaluation.
How the test is performedSee: Lumbar puncture.
How the test will feelFor detailed information, see the article on lumbar puncture.
Why the test is performedThis test is done to see if myelin, the substance covering your nerves, is breaking down. Myelin breakdown is called demyelination. Multiple sclerosisis the most common cause for this, but other causes may include:
- Bleeding of the central nervous system
- Central nervous system trauma
- Certain brain diseases (encephalopathies)
- Infection of the central nervous system
- Stroke
In general there should be less than 4 ng/mL of myelin basic protein in the CSF.
Note: ng/mL = nanogram per milliliter
Note: Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.
What abnormal results meanMyelin basic protein levels between 4 and 8 ng/mL may be a sign of a chronicbreakdown of myelin, or recovery from an acute episode of myelin breakdown.
If the myelin basic protein levels are greater than 9 ng/mL, myelin is actively breaking down.
What the risks areFor information on the risks of spinal tap, see: Lumbar puncture and CSF collection.
ReferencesGriggs RC, Jozefowicz RF, Aminoff MJ. Approach to the patient with neurologic disease. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier. 2007: chap 418.
What else can I help you with?
Why is csf protein in newborn is high normally?
Since blood-csf barrier is not well developed in neonates protein leak from blood to csf occurs...so csf protein is high in neonates and infants...for similar reason csf protein is elevated in all meningitis due to vascular permeability...
Would you find protein in cerebrospinal fluid?
Yes, protein can be found in cerebrospinal fluid (CSF). The normal protein concentration in CSF is much lower than in blood, typically ranging from 15 to 45 mg/dL. Elevated levels of protein in CSF can indicate various conditions such as infection or inflammation of the brain or spinal cord.
What is the removal of CSF?
In a lumbar puncture (LP) procedure, cerebrospinal fluid (CSF) is removed for analysis of protein, glucose, bacteria, etc., to assist in neurologic disease diagnosis.
Is too much protein bad in the cerebrospinal fluid?
Yes. Increased protein in the cerebrospinal fluid (CSF) can indicate inflammation or some other disorders. It may indicate an infection, such as meningitis. Other conditions, such as Multiple sclerosis, have increased proteins in the CSF.
What to expect from lab results in Guilliain-barre?
The typical finding in Cerebro Spinal Fluid(CSF) of Guillian- Barre syndrome is known as Albumino Cytological dissociation, which means high protein and a low cell count which does not go with the amount of protein detected in CSF.
Does cerebrospinal fluid have the exact same composition as blood plasma?
No, cerebrospinal fluid (CSF) does not have the exact same composition as blood plasma. CSF is produced by the choroid plexus in the brain and is an ultrafiltrate of plasma with lower protein and glucose levels but higher chloride concentrations. Additionally, CSF plays a role in cushioning the brain and spinal cord, as well as removing waste products.
What is in CSF?
CsF is the chemical formula of caesium fluoride.
What is the normal CSF chloride level and how it change in tuberculosis?
The normal cerebrospinal fluid (CSF) chloride level typically ranges from 120 to 130 mEq/L. In cases of tuberculosis meningitis, CSF chloride levels can be decreased due to the inflammatory process and increased permeability of the blood-brain barrier. This reduction in chloride levels, along with elevated protein and lymphocytic pleocytosis, can help differentiate tuberculosis from other forms of meningitis.
When was Colnago-CSF Bardiani created?
Colnago-CSF Bardiani was created in 1982.
Is glucose found in CSF fluid?
Yes, glucose is found in cerebrospinal fluid (CSF). Glucose is one of the primary sources of energy for the brain and is transported from the blood into the CSF to support normal brain function. Monitoring glucose levels in CSF is important in diagnosing certain neurological conditions.
What is the normal flora of CSF?
Cerebrospinal fluid (CSF) is typically a sterile fluid, meaning it should not contain any normal flora. The presence of bacteria in the CSF is abnormal and can indicate an infection, such as meningitis.
What is the compound formula of cesium fluoride?
The compound formula of cesium fluoride is CsF.
