Exogenous Cushing syndrome is a form of Cushing syndrome that occurs in people taking glucocorticoid (also called corticosteroid) hormones, such as prednisone.
Alternative NamesCushing syndrome - corticosteroid induced; Corticosteroid-induced Cushing syndrome; Iatrogenic Cushing syndrome; Exogenous Cushing syndrome
Causes, incidence, and risk factorsExogenous means caused by something outside the body. Exogenous Cushing syndrome occurs when a person takes human-made (synthetic) glucocorticoids, such as prednisone or dexamethasone, for treatment purposes (for example, to treat Asthma).
In Cushing syndrome, the adrenal glands produce too much of certain hormones, such as cortisol.
For other causes and more information about Cushing syndrome, see:
SymptomsSymptoms usually include:
Skin changes that are often seen:
Muscle and bone changes include:
Women often have:
Men may have:
Other symptoms that may occur include:
In people who use cortisone, prednisone, or other corticosteroids, the following test results may suggest exogenous Cushing syndrome:
A method called high performance liquid chromatography (HPLC) can show high levels of the suspected medication in the urine.
TreatmentThe suggested treatment is to slowly stop taking any corticosteroids. Do not stop taking any medicine without first talking to your health care provider.
If you cannot stop taking the medication because of disease (for example, if you need steroids to treat severe asthma), make every effort to reduce the possibility of developing complications.
Slowly withdrawing the drug causing the condition can help reverse the effects of adrenal gland shrinkage (atrophy), although this may take as long as a year. During this time, you may need to restart taking your steroids in times of stress.
ComplicationsThese complications can generally be prevented with proper treatment.
Calling your health care providerCall for an appointment with your health care provider if you are taking a corticosteroid drug and you develop symptoms of Cushing syndrome.
PreventionAwareness of the signs and symptoms of Cushing syndrome may make early treatment possible for patients who take corticosteroids. If you use inhaled steroids, you can decrease your exposure to the steroids by using a "spacer," and by rinsing your mouth after breathing in the steroids.
ReferencesStewart PM. The adrenal cortex. In: Kronenberg H, Melmed S, Polonsky K, Larsen PR, eds. Williams Textbook of Endocrinology. 11th ed. Philadelphia, Pa: Saunders Elsevier; 2008:chap 14.
Exogenous Cushing syndrome is a form of Cushing syndrome that occurs in people taking glucocorticoid (also called corticosteroid) hormones, such as prednisone.
Alternative NamesCushing syndrome - corticosteroid induced; Corticosteroid-induced Cushing syndrome; Iatrogenic Cushing syndrome; Exogenous Cushing syndrome
Causes, incidence, and risk factorsExogenous means caused by something outside the body. Exogenous Cushing syndrome occurs when a person takes human-made (synthetic) glucocorticoids, such as prednisone or dexamethasone, for treatment purposes (for example, to treat asthma).
In Cushing syndrome, the adrenal glands produce too much of certain hormones, such as cortisol.
For other causes and more information about Cushing syndrome, see:
SymptomsSymptoms usually include:
Skin changes that are often seen:
Muscle and bone changes include:
Women often have:
Men may have:
Other symptoms that may occur include:
In people who use cortisone, prednisone, or other corticosteroids, the following test results may suggest exogenous Cushing syndrome:
A method called high performance liquid chromatography (HPLC) can show high levels of the suspected medication in the urine.
TreatmentThe suggested treatment is to slowly stop taking any corticosteroids. Do not stop taking any medicine without first talking to your health care provider.
If you cannot stop taking the medication because of disease (for example, if you need steroids to treat severe asthma), make every effort to reduce the possibility of developing complications.
Slowly withdrawing the drug causing the condition can help reverse the effects of adrenal gland shrinkage (atrophy), although this may take as long as a year. During this time, you may need to restart taking your steroids in times of stress.
ComplicationsThese complications can generally be prevented with proper treatment.
Calling your health care providerCall for an appointment with your health care provider if you are taking a corticosteroid drug and you develop symptoms of Cushing syndrome.
PreventionAwareness of the signs and symptoms of Cushing syndrome may make early treatment possible for patients who take corticosteroids. If you use inhaled steroids, you can decrease your exposure to the steroids by using a “spacer,” and by rinsing your mouth after breathing in the steroids.
ReferencesStewart PM. The adrenal cortex. In: Kronenberg H, Melmed S, Polonsky K, Larsen PR, eds. Williams Textbook of Endocrinology. 11th ed. Philadelphia, Pa: Saunders Elsevier; 2008:chap 14.
Reviewed ByReview Date: 11/23/2009
Ari S. Eckman, MD, Division of Endocrinology and Metabolism, Johns Hopkins School of Medicine, Baltimore, MD. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
Cushing's Syndrome
E24.9 - Cushing's syndrome, unspecified
Cushing syndrome
"Cushing" refers to Cushing's syndrome, an issue that results from high exposures to the hormone cortisol. The syndrome will result in a tumor appearing on the pituitary gland.
Dorothy T. Krieger has written: 'Cushing's syndrome' -- subject(s): Cushing's syndrome
cortisol
Cushing Syndrome
Cushing syndrome affects the adrenal gland, which in return stimulates aldosterone. Aldosterone is responsible for salt and water retention. In Cushing syndrome cortisol is high which also blocks the excretion of sodium from the body.
True: Cushing syndrome affects more women than men. The hypersecretion of glucocorticoid hormone causes patients with Cushing syndrome to develop a characteristic moon face. Redistribution of body fat causes a buffalo hump on the upper back.
Cushing syndrome, Prader Willi syndrome, and Simpson-Golabi-Behmel Syndrome can all cause obesity.
adrenal oversecretion is a cause of Cushing's syndrome.
Endogenous hypercortisolism is known as Cushing's syndrome.