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DEET is an active ingredient in the majority of insect repellent sprays and lotions, and is extremely effective in preventing the bites from insects such as ticks and mosquitos. Ticks and mosquitos are known for carrying diseases that can cause severe physical conditions and complications including Lyme disease, encephalitis, and Rocky Mountain spotted fever. Products that contain DEET are deemed safe for use on children and adults, and it should be applied to an individual's clothing and all exposed skin. In the 1990s there was some concern regarding the safety of DEET, however the U.S. Environmental Protection Agency ultimately found that it does not present a health risk to humans.

Consumers will find that the concentration of DEET in a product will vary from 4 to 100% and they should consider how strong of a repellent they require based on needs. The strength needed will vary depending on whether someone plans on extended periods of camping or just enjoying a backyard picnic. It also affects how long the DEET will repel bugs for, usually from three to eight hours based on the product. When engaging in outdoor activities, there are other methods of preventing bug bites that should be utilized in combination with DEET sprays and creams. People who are hiking, hunting, or in an area of long grass or bushes should always wear long-sleeved shirts, pants, and closed footwear. It is also helpful to tuck pants legs into socks and shirts into pants for further prevention.

Following instructions on the bottle helps to ensure that DEET is used properly and safely. The benefits of using insect repellent exceed the risks and using it should become routine for people enjoying time outdoors. DEET-containing products should never be directly applied to the face. Individuals can spray their hands and then apply to sensitive areas in order to cover all exposed body parts, and young children should be assisted when applying DEET. It is not necessary to apply DEET under clothing and it is recommended that individuals wash all clothing worn and bathe upon return. Examining oneself upon return for any ticks and removing them promptly is critical for health.

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