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Fibrin degradation products (FDPs) are the substances left behind when clots dissolve in the blood. This article discusses the blood test to measure these products.
Alternative NamesFDPs; FSPs; Fibrin split products; Fibrin breakdown products
How the test is performedBlood is typically drawn from a vein, usually from the inside of the elbow or the back of the hand. The site is cleaned with germ-killing medicine (antiseptic). The health care provider wraps an elastic band around the upper arm to apply pressure to the area and make the vein swell with blood.
Next, the health care provider gently inserts a needle into the vein. The blood collects into an airtight vial or tube attached to the needle. The elastic band is removed from your arm.
Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.
In infants or young children, a sharp tool called a lancet may be used to puncture the skin and make it bleed. The blood collects into a small glass tube called a pipette, or onto a slide or test strip. A bandage may be placed over the area if there is any bleeding.
The blood is sent to a laboratory. The laboratory specialist will run tests on the blood sample to measure the products that are left behind when blood clots dissolve.
How to prepare for the testYour health care provider may tell you to stop taking certain drugs before the test. Drugs that may increase FDPs include barbiturates, heparin, streptokinase, and urokinase.
Do not stop taking any medicine without first talking to your doctor.
How the test will feelWhen the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.
Why the test is performedThis test is done to see if your clot-dissolving (fibrinolytic) system is working properly. Your doctor may order this test if you have signs of disseminated intravascular coagulation (DIC) or another clot-dissolving disorder.
Normal ValuesThe result is normally less than 10 micrograms per milliliter (mcg/mL).
Note: Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.
What abnormal results meanIncreased FDPs may be a sign of primary or secondary fibrinolysis (clot-dissolving activity) due to:
- Abruptio placentae
- Burns
- Congenital heart disease
- Disseminated intravascular coagulation (DIC)
- Hypoxia
- Infections
- Intrauterine fetal death
- Leukemia
- Liver disease(See: cirrhosis)
- Portacaval shunt
- Preeclampsia
- Recent blood transfusion
- Recent surgery that involved a heart and lung bypass pump
- Renal disease(See: kidney failure)
- Septicemia
- Thromboembolic states
- Transplant rejection
- Transfusion reaction
There is very little risk involved with having your blood taken. Veins and arteries vary in size from one patient to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.
Other risks associated with having blood drawn are slight but may include:
- Excessive bleeding
- Fainting or feeling light-headed
- Hematoma (blood accumulating under the skin)
- Infection (a slight risk any time the skin is broken)
Schafer AI. Hemorrhagic disorders: Disseminated intravascular coagulation, liver failure, and vitamin K deficiency. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 181.
What else can I help you with?
Which enzyme converts fibrin to fibrin degradation products?
Plasmin, a serine protease, is the enzyme responsible for converting fibrin into fibrin degradation products. Plasmin is activated from plasminogen in the presence of tissue plasminogen activator (tPA) or urokinase.
What is a fibrin degradation products test?
A fibrin degradation products (FDP) test is a blood test that measures the presence of fragments produced when fibrin, a protein involved in blood clotting, breaks down. Elevated levels of FDPs can indicate conditions such as disseminated intravascular coagulation (DIC), deep vein thrombosis, or pulmonary embolism. This test helps assess the body’s clotting and bleeding processes. It is often used in conjunction with other tests to diagnose clotting disorders or monitor treatment effectiveness.
What are fibrin?
Fibrin sealants are a type of surgical tissue adhesive derived from human and animal blood products. The ingredients in these sealants interact during application to form a stable clot composed of a blood protein called fibrin.
What are fibrin sealants?
Fibrin sealants are a type of surgical tissue adhesive derived from human and animal blood products. The ingredients in these sealants interact during application to form a stable clot composed of a blood protein called fibrin.
What color tube is used for FDP testing?
The color tube used for FDP (Fibrin Degradation Products) testing is typically a light blue top tube, which contains sodium citrate as an anticoagulant. This tube is used for coagulation studies to prevent blood from clotting.
What is another term for fibrin sealants?
Fibrin sealants are also called fibrin glues
The basic event in the formation of a blood clot is the change of what?
fibrinogen to fibrin.
What is D Dimer?
When a blood clot is broken up within the human body, it releases fibrin (the protein which causes clotting to occur). A D-dimer level measures the amount of fibrin within a blood sample (where the fibrin will float around), to help determine if a clot has been present.
Is fibrin found in the circulatory or respiratory system?
Fibrin is found in the Circulatory System.
What causes the formation of fibrin strands in a sample?
Fibrin strands form when fibrinogen is converted into fibrin by the enzyme thrombin during the blood clotting process. Thrombin acts on fibrinogen to create fibrin monomers, which then polymerize into a network of fibrin strands that help to trap platelets and form a stable blood clot.
When clot forms what does fibrin convert to?
fibrin molecules converting them into an insoluble meshwork - the clot
What is fibrin in horses and how can you treat it?
Fibrin is a specific type of protein that is involved in blood clotting.
