Hypopituitarism is a condition in which the pituitary gland does not produce normal amounts of some or all of its hormones.
Alternative NamesPituitary insufficiency
Causes, incidence, and risk factorsThe pituitary gland is a small structure that is located just below the brain. It is attached by a stalk to the hypothalamus, the area of the brain that controls its function.
The hormones released by the pituitary gland (and their functions) are:
In hypopituitarism, there is a lack of one or more pituitary hormones. Lack of the hormone leads to loss of function in the gland or organ that it controls. For example, no TSH leads to loss of function in the thyroid gland.
Hypopituitarism may be caused by:
Occasionally, hypopituitarism is due to uncommon immune system or metabolic diseases, such as:
Hypopituitarism is also a rare complication after pregnancy, a condition called Sheehan's syndrome.
SymptomsNote: Symptoms may develop slowly and may vary greatly, depending upon:
Other symptoms that may occur with this disease:
Signs and testsTo diagnose hypopituitarism, there must be low hormone levels due to a problem with the pituitary gland. The diagnosis must also rule out diseases of the organ that is affected by this hormone.
Tests include:
Levels of a pituitary hormone may be high in the bloodstream if you have a pituitary tumor that is producing too much of that hormone. The tumor may crush the rest of the cells of the pituitary, leading to low levels of other hormones.
TreatmentIf hypopituitarism is caused by a tumor, you may need surgery to remove the tumor, with or without radiation therapy. It is often necessary to replace hormones that are lacking, even after successful treatment of a pituitary tumor.
Hormone therapy is needed to replace hormones that are no longer made by organs under the control of the pituitary gland. These may include:
Drugs are also available to treat related infertility in men and women.
Expectations (prognosis)Hypopituitarism is usually permanent and requires lifelong treatment. However, you can expect a normal life span.
ComplicationsSide effects of drug therapy can develop. In severe illness, failing to take extra corticosteroids can be life-threatening.
Calling your health care providerCall your health care provider if you develop symptoms of hypopituitarism.
PreventionIn most cases, the disorder is not preventable. Awareness of risk may allow early diagnosis and treatment.
ReferencesMelmed S, Kleinberg D. Anterior pituitary. In: Kronenberg H, Melmed S, Polonsky K, Larsen PR, eds. Williams Textbook of Endocrinology. 11th ed. Philadelphia, Pa: Saunders Elsevier; 2008:chap 8.
Hypopituitarism is a condition in which the pituitary gland does not produce normal amounts of some or all of its hormones.
Alternative NamesPituitary insufficiency
Causes, incidence, and risk factorsThe pituitary gland is a small structure that is located just below the brain. It is attached by a stalk to the hypothalamus, the area of the brain that controls its function.
The hormones released by the pituitary gland (and their functions) are:
In hypopituitarism, there is a lack of one or more pituitary hormones. Lack of the hormone leads to loss of function in the gland or organ that it controls. For example, no TSH leads to loss of function in the thyroid gland.
Hypopituitarism may be caused by:
Occasionally, hypopituitarism is due to uncommon immune system or metabolic diseases, such as:
Hypopituitarism is also a rare complication after pregnancy, a condition called Sheehan's syndrome.
SymptomsNote: Symptoms may develop slowly and may vary greatly, depending upon:
Other symptoms that may occur with this disease:
Signs and testsTo diagnose hypopituitarism, there must be low hormone levels due to a problem with the pituitary gland. The diagnosis must also rule out diseases of the organ that is affected by this hormone.
Tests include:
Levels of a pituitary hormone may be high in the bloodstream if you have a pituitary tumor that is producing too much of that hormone. The tumor may crush other cells of the pituitary, leading to low levels of other hormones.
TreatmentIf hypopituitarism is caused by a tumor, you may need surgery to remove the tumor, with or without radiation therapy.
You will need lifelong hormone therapy to replace hormones that are no longer made by organs under the control of the pituitary gland. These may include:
Drugs are also available to treat related infertility in men and women.
Expectations (prognosis)Hypopituitarism is usually permanent and requires lifelong treatment. However, you can expect a normal life span.
ComplicationsSide effects of drug therapy can develop. In severe illness, failing to take extra corticosteroids can be life-threatening.
Calling your health care providerCall your health care provider if you develop symptoms of hypopituitarism.
PreventionIn most cases, the disorder is not preventable. Awareness of risk may allow early diagnosis and treatment.
ReferencesMelmed S, Kleinberg D, Ho K. Pituitary physiology and diagnostic evaluation. In: Kronenberg H, Melmed S, Polonsky KS, Larsen PR, eds. Williams Textbook of Endocrinology. 12th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 8.
Reviewed ByReview Date: 12/11/2011
Nancy J. Rennert, MD, Chief of Endocrinology & Diabetes, Norwalk Hospital, Associate Clinical Professor of Medicine, Yale University School of Medicine, New Haven, CT. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
There is no known prevention of hypopituitarism, except for prevention of damage to the pituitary/hypothalamic area from injury.
There are many known individuals that have been diagnosed with the issue of "Hypopituitarism." This condition is very likely to run in family circles.
yes...
Hypopituitarism
The pituitary gland
Yes. The movie "Orphan" (2009).
Yes. It's different for everybody.
It's a rare condition, and the cause it not yet known.
You would have to take special medications under a doctor's supervision.
Possibly. When the pituitary gland doesn't work, anything can happen.
Good question. You'll have to ask a doctor about that.
If it results in a lowered production of growth hormone then yes, dwarfism can result.