Nerve biopsy

Anonymous

∙ 14y ago

Updated: 11/10/2020

Definition

A nerve biopsy is the removal of a small piece of a nerve for examination.

Alternative Names

Biopsy - nerve

How the test is performed

The sural nerve (in the ankle), or the superficial radial nerve (wrist) are the sites most often used for biopsy. A local anesthetic is used to numb the area. A small incision is made, and a portion of the nerve is removed. The sample is then examined using either a regular (light) microscopic or an electron microscope. Individual nerve fibers may also be examined.

How to prepare for the test

There is no special preparation.

How the test will feel

The amount of pain during and after the procedure depends on the patient. Because a local anesthetic is used, discomfort during the procedure is usually minimal. The anesthetic may burn or sting when first injected. After the procedure, the area may feel tender or sore for a few days.

Why the test is performed

Nerve biopsy may be done to help diagnose:

Axon degeneration (destruction of the axon portion of the nerve cell)
Damage to the small nerves
Demyelination(destruction of parts of the myelin sheath covering the nerve)
Inflammatory nerve conditions (neuropathies)

Normal Values

There is normal nerve anatomy, with no abnormal growths or inclusions.

Note: Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.

What abnormal results mean

Conditions or disorders that may be revealed include:

Amyloidosis(sural nerve biopsy is most often used)
Demyelination
Inflammation of the nerve
Leprosy
Loss of axon tissue
Metabolic neuropathies
Necrotizing vasculitis
Sarcoidosis

Additional conditions under which the test may be performed:

What the risks are

Allergic reaction to the local anesthetic
Discomfort after the procedure
Infection (a slight risk any time the skin is broken)
Permanent nerve damage (uncommon; minimized by careful site selection)

Special considerations

Nerve biopsy is invasive and is useful only in certain circumstances. These include diagnosis of asymmetric and multifocal nerve disorders, conditions in which a nerve enlargement can be felt with the fingers, and suspected inherited pediatric nerve disorders.

References

Shy ME. Peripheral neuropathies. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier. 2007: chap 446.

Wiki User

∙ 14y ago

What else can I help you with?

Why is a nerve biopsy performed?

A nerve biopsy is performed to detect nerve-damaging conditions, including leprosy, necrotizing vasculitis (an inflammation of the blood vessels), other nerve inflammation, and damage or loss of the nerve's protective myelin sheath.

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Nerve biopsies are performed in the more serious conditions. The biopsy will permit the physician to see the actual condition of the nerve and rule out other causes for the pain the patient experiences.

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