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Depo-Provera (depomedroxyprogesterone acetate) can take several months to fully leave your system after the last injection. The medication's effects can last anywhere from 3 to 12 months, depending on individual metabolism and other factors. Generally, it may take about 10 months for fertility to return to normal after the last shot, although some women may conceive sooner. Always consult with a healthcare provider for personalized advice.

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