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It depends on what context you are referring to, however, for these purposes, we will assume that this is a chemistry question.

In chemistry, F2 is the formula for fluorine gas. Elemental fluorine consists of molecules in which two fluorine atoms are covalently bonded, meaning that share electrons. Fluorine is an extremely reactive toxic gas that will readily set most substances on fire.

F- refers to the fluoride ion, which consists of a single fluorine atom with an extra electron, giving it a negative charge. As an ion it cannot exist on its own, but must be accompanied by some positive ion such as sodium (Na+). Such fluoride compounds are far more stable than fluorine gas.

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