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To replace the radio in a 2003 E-350, start by disconnecting the negative battery cable to ensure safety. Remove the trim panel around the radio using a flat-head screwdriver or trim tool, then unscrew the mounting screws holding the radio in place. Carefully pull the radio out, disconnect the wiring harness and antenna, then connect the new radio’s wiring harness and antenna. Finally, secure the new radio with screws, reattach the trim panel, and reconnect the battery.

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