You'll need to provide more information with your question, before I can possibly provide an answer. How did you determine the cylinders #1 & #8 are misfiring? Did the "Service Engine Soon" light come on? If so, have you connected an engine diagnostic reader to read the trouble code(s)? As you may knwo, your local auto parts store can loan you the diagnostic reader, and assist you in reading the code(s).
What causes misfire 302, 304 and 306
a bad coil or plug to be safe change both
Random misfire, cylinder 2 misfire, and cylinder 3 misfire. see related question below.
random/multiple cylinder misfire!
The exact cost to fix an engine cylinder misfire on a 2000 Mercury Mystique will depend on the exact type of engine it has, but can cost around $1,000.
Cylinder Number 1 Misfire Detected
Cylinder 1 Misfire Detected
Code P0304: Misfire at cylinder 4 detected.
Cylinder #2 Misfire
A P1399 code is a cylinder 1 misfire code
drivers side of engine , front cylinder
Most commonly a bad plug or wire. If not that, then coil.