The Native Americans are a perfect example of what happens when the Old world meets the new world. They died of diseases, were discriminated against, moved off of ancestral lands, and segregated.
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It resulted in disease outbreaks that devastated native populations.
The United States constitution gave Native Americans the right to vote in 1924, until this date Native Americans were not considered citizens. There are treaties that were signed by the various tribes that included the Native peoples into the constitution of the United States.
There are two possible reasons ( others may exist as well ) for Spain's attempts to Christianize the Native Americans in the New World. One reason was the sincere belief that by doing so, they were helping these Native Tribes to discover God and thus establish a relationship with their Creator. This could have been a sincere goal. The other reason would be to bring the Native Americans into the "fold" of Catholic Spain, and thus have a measure of commonality among the two peoples. It must be remembered that "religion" was a stronger force in the colonail days of Spain then perhaps it is now.
Any people isolated unto themselves will not have ordinary immunities common in other peoples from other countries. So, Europeans exposed Native Americans to viruses and bacteria common to that time. A common cold could override immune systems if a people had never been exposed to that virus before.
they picked them out of there land and gave them sicknesses!