The first president chose the federal officials on his their qualifications and from his support.
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George Washington
I beleive its Theodore Roosevelt
The house of Representatives but the Supreme Court must approve of it first.
The president, vice-president and federal judges can be removed from office for committing crimes. First the person must be officially charged with a crime or crimes, this is called impeachment, and then the person must stand trial in the Senate where a conviction requires a 2/3 vote. Members of Congress, however, are not subject to this process.
Mary McLeod Bethune was the first African American woman to head a federal agency