The US Senate can refuse to confirm appointments to the Judicial Branch.
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The Legislative Branch
According the United States Constitution, the US Senate can refuse the president's appointments. It can also reject treaties that have been agreed to by the president.
The Senate has the power to try all impeachments, confirmation of appointments (i.e. Supreme Court Justices), and ratification of treaties.
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It falls to the Senate to approve appointments made by the President of the United States. These appointments encompass the Department of Justice, ambassadors, deputy secretaries, US attorneys, and general counsels.