Anwar Sadat
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When Lincoln was assassinated, Vice President Andrew Johnson became the new President. No new Vice President was chosen; the office was vacant until Ulysses Grant was elected President in 1868 and Schuyler Colfax became Vice President. This is why the Constitution was amended in 1967, with the 25th Amendment. It finally set rules for how a new Vice President is chosen when the sitting Vice President has to take over the Presidency.
John Adams was the first US vice-president.
john Adams was the first vice president in 1789
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The first vice president to take over office was John Tyler.