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Schistosomes are unique among trematodes due to their dioecious reproductive system, meaning they have distinct male and female individuals, whereas most trematodes are hermaphroditic. They also have a complex life cycle that includes specific freshwater snail hosts for their larval stages, which is less common in other trematodes. Additionally, schistosomes are known for causing significant human diseases, such as schistosomiasis, making their public health impact more pronounced compared to other trematodes. Their elongated body shape and specialized structures for attachment and movement further differentiate them from other trematodes.

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