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Dr. James's experiments on frogs are significant to "Frankenstein" as they explore themes of life creation and the ethical implications of scientific experimentation. These experiments serve as a precursor to Victor Frankenstein's endeavors to animate the creature, highlighting the tension between scientific ambition and moral responsibility. They underscore the novel's exploration of the consequences of playing God and the quest for knowledge without considering the ramifications. Through these parallels, Shelley critiques the hubris of unchecked scientific exploration.

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