The invading Eurpeans (Hernan Cortez, et al) spread diseases like smallpox and measles, against which the Aztecs had no immunity. Thousands and thousands of the Aztecs died, to the point that they could no longer fight against the invaders.
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The Spanish Destroyed The Aztec... Cortes Was The Leader and the army
Spain.
Spanish invaders that conquered the Aztecs were way more advanced and were believed to be gods by the Aztexs when they first arrived. The Spanish also had the help og the Aztecs rival tribes.
The Incas never took over the Aztecs. Both were destroyed by the Spanish Conquistadors in the early 16th century.
After the Spaniards captured the Aztec city, they destroyed everything and stole the valuable gold.