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The fall of the Aztec Empire was primarily due to the arrival of Spanish conquistadors, led by Hernán Cortés, in 1519. Their advanced weaponry, along with alliances with discontented indigenous groups, significantly weakened the Aztecs. Additionally, the spread of diseases such as smallpox devastated the indigenous population, further contributing to the empire's collapse. The combination of military conquest, strategic alliances, and epidemics ultimately led to the downfall of the Aztec civilization.

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