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One key factor that helped Hernán Cortés conquer the powerful Aztec Empire was his ability to form alliances with various indigenous groups who were resentful of Aztec rule. These alliances provided him with additional manpower and local knowledge, which proved crucial in navigating the complex political landscape of the region. Additionally, the spread of diseases like smallpox, which decimated the Aztec population, weakened their ability to resist the Spanish conquest.

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