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Nematodes (the more correct name for Roundworms) are slender worms, typically less than 2.5 mm (0.098 in) long. The smallest nematodes are microscopic, while free-living species can reach as much as 5 cm (2.0 in), and some parasitic species are larger still, reaching over a meter in length. The body is often ornamented with ridges, rings, bristles, or other distinctive structures.

The head of a nematode is relatively distinct. Whereas the rest of the body is bilaterally symmetrical, the head is radially symmetrical, with sensory bristles and, in many cases, solid 'head-shields' radiating outwards around the mouth. The mouth has either three or six lips, which often bear a series of teeth on their inner edges. An adhesive 'caudal gland' is often found at the tip of the tail.

The epidermis is either a synctium or a single layer of cells, and is covered by a thick collagenous cuticle. The cuticle is often of complex structure, and may have two or three distinct layers. Underneath the epidermis lies a layer of longitudinal muscle cells. The relatively rigid cuticle works with the muscles to create a hydroskeleton as nematodes lack circumferential muscles. Projections run from the inner surface of muscle cells towards the nerve cords; this is a unique arrangement in the animal kingdom, in which nerve cells normally extend fibres into the muscles rather than vice versa.

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