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They are both from different systems. Hormones are from the endocrine system and neurotransmitters are from the nervous system. They both also have different ways of how they communicate with the body to change or have a reaction. Hormones travel through the blood to the location that needs to be changed or balanced. Neurotransmitters travel along nerves. A third thing is that they affect the body differently. Hormones affect the systems that we generally don't notice, like our growth. Whereas neurotransmitters our typically immediately noticed, like tickling or pain.

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