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An animal's endoskeleton grows through a process called appositional growth, where new bone tissue is added to the outer surface while the internal structure is maintained. This growth is facilitated by specialized cells called osteoblasts, which produce bone matrix, and osteoclasts, which break down old bone tissue. Hormones such as growth hormone and sex hormones also play a critical role in regulating this growth process. Additionally, factors like nutrition and mechanical stress influence the development and adaptation of the endoskeleton.

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