What is RBC life cycle?

Answer 1

1. macrophages phagocitize worn out RBC's in liver and spleen.

2. hemoglobin is split into heme and globin

3. globin is broken down into amino acids

4. iron is removed from here and transported to the liver via transferrin

5. iron is stored as ferritin in the liver

6. iron is released from storage, reattaches to transferrin and is transferred to bone

7. iron is reused to make new hemoglobin

8. new RBC's are made and released into circulation

9. heme is converted to biliverdin then to bilirubin

10. bilirubin is transported to the liver

11. bilirubin is relaeased into bile into the duodenum then into the large intestine

12. bacteria convert bilirubin into urobilinogen

13./14. Urobilinogen is converrted into urobilin and stercobilin and excreted