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In the 1960's when immunoglobulin nomenclture was finally decided, names were given based on their respective features. Hence lgG stands for gamma-globulin (gamma region of mobility), lgA for alpha-globulin (no immunoglobulin fraction was found in the alpha region) and lgM for macro-globulin (is a protein macroglobulin and is the largest globulin/antibody in the human body).

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