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Disease, particularly smallpox, played a significant role in Hernan Cortes's success during the Spanish conquest of the Aztec Empire. Smallpox epidemics decimated the native population, weakening the Aztec resistance and paving the way for Cortes's forces to conquer the region more easily. This demographic catastrophe, combined with the aid of indigenous allies and superior weaponry, contributed to Cortes's ultimate victory.

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