Yes it was painted in the 1500s
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It is an oil painting on canvas.
He made a fresco of nude people and it had to be amended because nudity was not acceptable in 1500s.
Most of all oil painting.
He made many, among these , his most famous paintings, the Mona Lisa, and the painting of the Last Supper. He also drew invention designs for things like the calculator. That is, if you're talking about Leonardo Da Vinci.
The 'Geurnica' was a Pablo Picasso painting made after the bombing in Guernica. He made the painting from April 26, 1937 until June 1937.