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Frank Starling's law of the heart refers to a length-tension relationship of cardiac muscle cells. As ventricles fill with blood, the extra blood causes a stretch of the muscle cells known as end diastolic volume. The greater the stretch, within limits, the greater the contractile force, and therefore the greater the ability to eject blood from the ventricles (end systolic volume) to the great vessels, pulmonary trunk or aorta.

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