There are two ways of measuring Rheumatoid factor in blood
The information that I have found so far claims that Human decidua-associated protein (hDP) 200 identified as a monoclonal rheumatoid factor is not an acute phase reactant. See the related link (Is rheumatoid factor an acute phase protein)for more information on this subject.
At this stage the reason for rheumatoid factor is still unknown.
Rheumatoid factor (RF or RhF) is an antibody that attacs an organism's own tissue. omos often found in About 80% of people with rheumatoid arthritis have detectable rheumatoid factor. Those who do not are said to be "seronegative".Rheumatoid factor can also be a (antibody that precipitates on cooling of a blood sample); it can be either type 2 (monoclonal IgM to polyclonal IgG) or 3 (polyclonal IgM to polyclonal IgG)
A rheumatoid factor over 23 units and a titer over 1:80 indicates rheumatoid arthritis, However this may also occur in other conditions.False positive results can occur when the blood is high in fats.A negative test result for rheumatoid factor does not exclude the diagnosis of rheumatoid arthritis.
rheumatoid factor is a particular type of antibody that is found in about 80% of people have Rheumatoid arthritis as well as with other inflammatory illnesses. A negative RF simply means there is no RF in the blood.
The information that I have found so far claims that Human decidua-associated protein (hDP) 200 identified as a monoclonal rheumatoid factor is not an acute phase reactant. See the related link (Is rheumatoid factor an acute phase protein)for more information on this subject.
Yes, as a matter of fact you can have RA with no rheumatoid factor at all.
At this stage the reason for rheumatoid factor is still unknown.
It seems that rheumatoid factor is the only name that is used for it.
Rheumatoid factor (RF or RhF) is an antibody that attacs an organism's own tissue. omos often found in About 80% of people with rheumatoid arthritis have detectable rheumatoid factor. Those who do not are said to be "seronegative".Rheumatoid factor can also be a (antibody that precipitates on cooling of a blood sample); it can be either type 2 (monoclonal IgM to polyclonal IgG) or 3 (polyclonal IgM to polyclonal IgG)
A rheumatoid factor test measures the amount of rheumatoid factor in your blood. Rheumatoid factors are proteins produced by your immune system that can attack healthy tissue in your body.High levels of rheumatoid factor in the blood are most often associated with autoimmune diseases, such as rheumatoid arthritis and Sjogren's syndrome. But rheumatoid factor may be detected in some healthy people, and people with autoimmune diseases sometimes have normal levels of rheumatoid factor.Results are usually reported in one of two ways:Less than 40-60 u/mLLess than 1:80 (1 to 80) titerA low number (normal result) usually means you do not have rheumatoid arthritis or Sjogren syndrome. However, some people who do have these conditions still have a "normal" or low rheumatoid factor (RF).Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.What Abnormal Results MeanAn abnormal result means the test is positive, which means higher levels of rheumatoid factor have been detected in your blood. Most patients with rheumatoid arthritis or Sjogren syndrome have positive RF tests.The higher the level, the more likely one of these conditions is present. There are also other tests for these disorders that help make the diagnosis.Not everyone with higher levels of rheumatoid factor has rheumatoid arthritis or Sjogren syndrome.Your provider may do another blood test (anti-CCP antibody) to help diagnose rheumatoid arthritis.People with the following diseases may also have higher levels of rheumatoid factor:SclerodermaSystemic lupus erythematosusAdult Still's diseaseDermatomyositisSarcoidosisHigher-than-normal levels of RF may be seen in people with other medical problems. However, these higher RF levels cannot be used to diagnose these other conditions:
You can have it with or without any factor.
A rheumatoid factor over 23 units and a titer over 1:80 indicates rheumatoid arthritis, However this may also occur in other conditions.False positive results can occur when the blood is high in fats.A negative test result for rheumatoid factor does not exclude the diagnosis of rheumatoid arthritis.
The rheumatoid factor test is a commonly ordered laboratory test to help rheumatologists diagnose rheumatoid arthritis (RA). To conduct the test, a blood sample is collected from a vein using a needle. The sample is then sent to the laboratory for analysis. The lab will examine the blood to measure the rheumatoid factor, which is a protein produced by the immune system that can attack healthy tissues in a person’s body. High levels of rheumatoid factor can often be a good indicator of an RA diagnosis. In fact, seventy to ninety percent of people who are diagnosed with RA have a positive rheumatoid factor test. If a diagnosis of RA is in fact confirmed, the amount of rheumatoid factor in the patient’s blood may also help their doctor choose an appropriate treatment approach. However, although the rheumatoid factor test is a very useful diagnostic tool, it is important to remember that it is not conclusive of an RA diagnosis. Rheumatoid factor can be found in the blood samples of people without rheumatoid arthritis or in the samples from people who have different autoimmune conditions. It is also possible for someone who does have RA to have no rheumatoid factor present, particularly in the early stages of arthritis, although these cases of RA are generally less severe. Unfortunately there is no single test that can be used to confirm a diagnosis of RA. Instead, rheumatologists must rely on a combination of medical history, clinical exams, and various test results, including the rheumatoid factor test, to confirm a diagnosis of RA.
rheumatoid factor is a particular type of antibody that is found in about 80% of people have Rheumatoid arthritis as well as with other inflammatory illnesses. A negative RF simply means there is no RF in the blood.
No.
no one knows.