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Pacemaker cells inside the sinoatrial node in the right atrium spontaneously undergo action potentials at the rate of about 100 beats per minute. While you're alive, innervation from the autonomic system adjusts this rate to suit. These action potentials cause the cardiac muscle to contract, no input from the brain is necessary. As long as the heart muscle has enough energy, oxygen and ions etc that it requires it will continue to beat.

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