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I'd say, only if the toxin level in the blood is considered to be high, and then come off of it gradually, maybe a half mg a week. Also, try to replace that which is missing with some other medication because digoxin affects the pulse. During this time, continually check your pulse, if it goes up to the 90's and 100's after sleeping, go see a cardiologist. My mother is on digoxin, a few months ago her doc found that her toxin level was high. She was doing great though, she'd eat and walk all over the super market. Well at the time she was taking 250mg with a pulse averaging in the upper 50's. Due to the toxin level "only" the doc went out on a limb and immediately reduced her daily dosage by about 75% to .0625mg. Immediately afterward, she slept and slept and slept. She became weak and lost her appetite. She simply had little or no energy. While sleeping in the chair, her pulse went from averaging in the upper 50's and lower 60's to averaging in the 90's and low 100's . The doc was told about this but he was reluctant to increase her dosage or do anything on her behalf. This was an utterly ridiculous and unacceptable turn of events. After being on this .0625mg for about a month, the doc increased her dosage to 125mg. Well, after a little exertion, she began experiencing severe shortness of breath and a rapid heart rate. Just a week or so ago she collapsed and had a mini stroke and was rushed to the hospital by ambulance. She quickly recovered from the stroke, they ran a test and found liquid around her lungs. The possible reason is the left ventricle can't pump out enough blood, it gets backed-up in the lungs (behind the left ventricle), causing pulmonary edema, a build-up of fluid in the lungs. Among other things, this brings about shortness of breath. Keep in mind, this has not been confirmed by a doctor yet, but if this is indeed the case, then it had everything to do with the considerable decrease in her digoxin dosage. Of course, my mother's age and health situation may be a little different than yours but I'd have to say that her problems began immediately after her dosage was "considerably" reduced. Maybe coming off of it gradually is the only proper way to go about it but it may be a little too late for experimenting like that.

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Q: If heart rate is below 60 should digoxin dosage be reduced?
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You need to accurately check the heart rate. Digoxin can lower the heart rate to dangerous levels. You should not administer digoxin when pulse rate is already below 60.


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