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Like many other advances in science, invention of the CT scanner was not a singular event, but the product of advances at the forefront of science and technology. Ledley's greatest contributions to science, in fact, occurred decades before when he laid out the principles of applying computers in medicine (See: Reasoning Foundation of Medical Diagnosis) and computerized image analysis. When computers became sufficiently powerful to allow reconstruction of transferse images, Ledley was in the forefront, along with Godfrey Hounsfield in developing such machines. Hounsfield's machine was first, but very limited in its applications since it could not effectively reconstruct images including air or bone. Ledley's machine built on his previous success in building computers for pattern recognition and image analysis, and used mathematical algorithms developed by Allan Cormack. The Ledley machine (termed the ACTA) was the first that could effectively image large portions of the body, and he received the patent for this invention.

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