What is pharmacologic management of ventricular fibrillation?

Answer 1

Patients who experience ventricular fibrillation (which is disorganized electrical activity occuring within the lower chambers of the heart) are resuscitated via defibrillation. Defibrillation consists of an electric shock usually delivered via conductive pads or paddles. It essentially resets all the cells of the heart in hopes that when electrical activity resumes, it will be organized and able to pump blood.

Untreated, all ventricular fibrillation is fatal, and patients who are at known risk for experiencing this arrythmia can be provided with an implanted cardioverter defibrillator, or ICD. This is a device which is placed under the skin of the upper torso and connected to the heart with a wire. It contains a computer which will monitor the patient's heart at all times and deliver a shock if recognizes ventricular fibrillation or a related rhythm called ventricular tachycardia.

There are also certain drugs, such as amiodarone and lidocaine, which can be given to a patient at known risk for ventricular fibrillation in order to make it less likely. These drugs usually work by making the cell membranes of the cells of the heart more electrically stable. Many of the same drugs can also be given if defibrillation is initially unsuccessful in order to help make it more effective.

It should be noted that there is a very short window of time to treat ventricular fibrillation (permenant brain damage begins to occur approximately 4-6 minutes after the onset of the arrythmia), and the prognosis for these patients is generally very poor if they are not defibrillated immediately and transferred to a critical care setting.

Answer 2

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