What will be the worst condition in Cushing syndrome?

Answer 1

Cushing syndrome may be caused by taking too much corticosteroid medications, such as prednisone and prednisolone. These drugs are used to treat conditions such as Asthma and rheumatoid arthritis.

Other people develop Cushing syndrome because their bodies produce too much cortisol, a hormone normally made in the adrenal gland. Causes of too much cortisol are:

Cushing's disease, when the pituitary gland makes too much of the hormone ACTH. ACTH then signals the adrenal glands to produce cortisol. Tumor of the pituitary gland may cause this condition.

Tumor of the adrenal gland

Tumor elsewhere in the body that produces cortisol

Tumors elsewhere in the body that produce ACTH (such as the pancreas, lung, and thyroid)

Symptoms

Most people with Cushing syndrome will have:

Upper body obesity (above the waist) and thin arms and legs

Round, red, full face (moon face)

Slow growth rate in children

Skin changes that are often seen:

Acne or skin infections

Purple marks (1/2 inch or more wide) called striae on the skin of the abdomen, thighs, and breasts

Thin skin with easy bruising

Muscle and bone changes include:

Backache, which occurs with routine activities

Bone pain or tenderness

Collection of fat between the shoulders (buffalo hump)

Thinning of the bones, which leads to rib and spine fractures

Weak muscles

Women with Cushing syndrome often have:

Excess hair growth on the face, neck, chest, abdomen, and thighs

Menstrual cycle becomes irregular or stops

Men may have:

Decreased fertility

Decreased or no desire for sex

Impotence

Other symptoms that may occur with this disease:

Mental changes, such as depression, anxiety, or changes in behavior

Fatigue

Headache

High blood pressure

Increased thirst and urination