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The metabolism of corticosteroids and corticotropin (ACTH) are increased in patients with hyperthyroidism and decreased in patients with hypothyroidism. But, if your hypothyroidism is treated and controlled by Synthroid (levothyroxin), you don't have to worry about this aspect.

Additionally, short-term administration of large corticosteroid doses (i.e., dexamethasone) may decrease serum T3 concentrations by 30%, and long-term corticosteroid therapy may result in decreased thyroid binding globulin production, causing slightly decreased T3 and T4 concentrations. Therefore, you can experience changes in how your thyroid medication works and caution should be taken when initiating, changing or discontinuing thyroid or cortisone related agents.

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