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Their exoskeleton limits growth; if arthropods were large, their armour would be too heavy and they'd collapse! Also they use trachea to absorb oxygen, and if they were large, these wouldn't reach through their entire body and cells would die off in areas further away from the oxygen supply. This is why they did get large in the Carboniferous era, when oxygen concentrations in the atmosphere were much higher. :)

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Q: Why can't arthropods be large?
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