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Gigantism is growth hormone excess prior to puberty and acromegaly is GH excess once one is a fully grown adult.

Gigantism:

1. If increased growth hormone occurs before puberty

2. Includes excessive length of bones, coarsening of the facial bones

3. Sexual development is usually slowed, mentally normal or slow

4. Usually result of tumor, surgical removal, radiation, drug therapy are treatment

5. Prognosis is good

Acromegaly:

1. Increased in growth hormone occurs after puberty

2. thickening and coarsening of bones, enlargement of lips, nose, jaw, thickening of tongue and skin.

3. Shortens life expectancy and often leads to CHF

4. Usually caused by tumor which may also affect vision

5. Surgical resection or radiation is Treatment, but this leads to hypopituitarism and tumors tend to reoccur.

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