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Forms of intravenous injection and infusion began as early as 1670. However, Charles Gabriel Pravaz and Alexander Wood were the first to develop a syringe with a needle fine enough to pierce the skin in 1853.

Benjamin A. Rubin invented the "Pronged Vaccinating and Testing Needle" or vaccination needle. This was a refinement to the conventional syringe needle.

In 1955, Roehr Products introduced a plastic disposable hypodermic syringe called the Monoject.

The microneedle device is a painless alternative to the needle and syringe. Mark Prausnitz, a chemical engineering professor from the Georgia Institute of Technology teamed together with electrical engineer Mark Allen to develop the prototype microneedle device, which looks like the nicotine quit smoking patch. The microneedle is made up of 400 silicon-based microscopic needles, each the width of a human hair. The tiny, hollow needles are so small, that any medication can be delivered through the skin without reaching the nerve cells that create pain. Microelectronics within the device would control the time and dosage of the medicine delivered.

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