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Columbus's relationship with the indigenous peoples he encountered evolved from initial curiosity and cooperation to exploitation and hostility. Initially, he sought alliances and trade, but as he aimed to establish Spanish dominance and extract resources, his approach became increasingly oppressive. This shift was driven by the demands of the Spanish crown for wealth and territory, leading to a legacy of colonization and violence against native populations. Over time, his relationships deteriorated, culminating in resistance and conflict with the very people he once sought to engage.

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