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Michael Collins' son, Patrick, died in 2021 at the age of 39 due to natural causes related to a long-standing health issue. He had been battling a rare form of cancer known as glioblastoma, which is an aggressive brain tumor. Collins spoke publicly about his son's illness and the challenges it presented for their family. Patrick's passing was a profound loss for Collins, who had previously faced significant challenges during his own career as an astronaut.

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