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The only deaths in space were the three crew of Soyuz 11 on June 30 1971, who died when their cabin depressurized at an altitude of 168km. The official definition of the beginning of space is 100km, so they just qualify. All the other space-related deaths have been on the ground, during launch, or re-entry below 100km.

3, all members of the crew of Soyuz 11. One more died on landing (Soyuz 1). 14 US astronauts have died in spacecraft in flight (Challenger and Columbia), although all were within the atmosphere, and therefore did not die in space.

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16y ago

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