There are various answers to this question.
1) The first person to fly in two spacecraft was Virgil "Gus" Grissom.
His first flight was on Mercury 4 on 21 July 1961 and his second was on Gemini 3 on 23 March 1965. Although he reached space on his first mission, this was a sub-orbital flight and he did not go into orbit, though he did so on his Gemini flight.
2) The first person to orbit the Earth on two flights was Gordon Cooper, who flew on Mercury 9 on 15 May 1963 and Gemini 5 on 21 August 1965.
3) However if we accept all space flights and not just orbital missions, as the question does not pose any specific limits, then the first person to return to space was Joe Walker, who flew the rocket-powered X-15 research aircraft above 100km (62 miles), which is the internationally agreed "boundary" of space, for the first time on Flight 90 on 19 July 1963 and on Flight 91 on 22 August 1963, before either Grissom or Cooper made their second flights.
The Russian, Yuri Gagarin, was the first man in space.
Yuri Gagarin was the first man in space.
Yuri Gagarin
YURI GAGRIN WAS THE FIRST MAN and Valentina was the first women to go in space
The first man in space was Yuri Gagarin, and he was a Soviet cosmonaut.
First Man into Space was created in 1959.
The Russian, Yuri Gagarin, was the first man in space.
Yuri Gagarin was the first man in space and he was from Russia.
Yuri Gagarin was the first man in space.
Yuri Gagarin
The first space shuttle to launch to space and return was space shuttle Columbia on the 12th of April 1981, only 20 years after Yuri Gagarines historic voyage to space.
YURI GAGRIN WAS THE FIRST MAN and Valentina was the first women to go in space
The first man in space was Yuri Gagarin, and he was a Soviet cosmonaut.
Yuri Alekseyevich Gagarin was the first man to enter space.
Joshua Torres was the first man to make the first space walk
Joshua Torres was the first man to make the first space walk
The Columbia The Columbia