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The asymmetric Strecker synthesis is a method used to prepare chiral α-amino nitriles from aldehydes and primary amines. In the case of clopidogrel, the synthesis involves the formation of the chiral α-amino nitrile, which is subsequently converted into the desired thienopyridine structure through further chemical reactions. The final steps in the synthesis involve the introduction of the clopidogrel-specific moieties to complete the synthesis of clopidogrel.
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What is an asymmetric synthesis?
An asymmetric synthesis is the synthesis of a specific enantiomer of a compound, a mixture containing more of one enantioner than another.
What has the author Mark A Rizzacasa written?
Mark A. Rizzacasa has written: 'Stoichiometric asymmetric synthesis' -- subject(s): Asymmetric synthesis, Stoichiometry
What has the author Benjamin List written?
Benjamin List has written: 'Science of synthesis' -- subject(s): Catalysis, Asymmetric synthesis, Carbon compounds 'Asymmetric organocatalysis' -- subject(s): Asymmetric synthesis, Organic Chemicals, Organic compounds, Organokatalyse, Asymmetrische Synthese, Catalysis, Synthesis, Chemical synthesis, Amines
What has the author J Seyden-Penne written?
J. Seyden-Penne has written: 'Chiral auxiliaries and ligands in asymmetric synthesis' -- subject(s): Asymmetric synthesis, Chirality
What is a binaphthol?
A binaphthol is any of several phenols derived from binaphthalene, especially 1,1'-bi-2-naphthol used in asymmetric synthesis.
What is asymmetric synthesis?
When a compound containing an asymmetric carbon atom is synthesised by ordinary laboratory methods from a symmetric compound ,the product is a racemic mixture.if ,however ,such a synthesis is carried under the asymmetric influence of a suitable optically active reagent ,only one of the optically active isomers ( or-)is formed.This process in which an asymmetric compound is synthesised from a symmetric compound to yield the ( ) isomer or (-)isomer directly is termed asymmetric synthesis.
Explain the Strecker synthesis with mechanism?
The Strecker synthesis is a method for synthesizing amino acids from aldehydes or ketones using ammonia, cyanide, and an acid catalyst. In the mechanism, ammonia adds to the carbonyl group to form an imine, which then reacts with cyanide to produce an α-aminonitrile intermediate. Acid hydrolysis of the α-aminonitrile results in the formation of an amino acid.
What has the author John P Cahill written?
John P. Cahill has written: 'The Preparation and Application of Diphenylphosphinopyrrolidine Ligands in Asymmetric Catalysis' -- subject(s): Chirolity, Asymmetric synthesis, Ligands
What has the author Yvonne M Malone written?
Yvonne M. Malone has written: 'The preparation and application of diphenylphosphinoferrocenyloxazoline ligands in asymmetric catalysis' -- subject(s): Catalysis, Asymmetric synthesis, Ligands
What is the birth name of Carl Strecker?
Carl Strecker's birth name is Carl Strecker.
What is hydrobenzoin used for?
It has been said that hydrobenzoin is the most useful chiral diol. It's chirality makes it extremely important for asymmetric synthesis where it has applications both stoichiometrically and catalytically. Check out 'Synthesis and application of chiral hydrobenzoin' by Kazuya Okano
When was Benjamin Strecker born?
Benjamin Strecker was born in 1982.
