The black death was a dark event in world history, Edgar Allan Poe wrote about many dark things so I guess all the death and tragic things during the black death sculpted his writing, his life wasn't very easy either.
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The black death epidemic did not directly affect Edgar Allan Poe's writing, as he lived in a different time period. However, Poe's work often delves into themes of death, decay, and mourning, which could have been influenced by the prevalence of death and disease in his 19th-century society.
No, although he did use it on occasion, there is no evidence that he was addicted to it.
Edgar Allan Poe's depression caused great strain on his life. The signs of his depression were apparent through his poems until he eventually drank himself to death.
It had no effect, since he did not use it personally. Some narrators in some of his stories used opium for literary effect.