What is Dale Harding's problem with his wife?

Answer 1

Harding is gay, and has chosen to marry Vera because she is the "epitome" of beauty and he hopes that she'll be able to sway his sexuality, which is why he booked himself into the institution.

Answer 2

Dale Harding's problem with his wife is that she is controlling and always wants to be in charge, causing conflict in their relationship. He feels suffocated and frustrated by her behavior.